ShamefurDispray

Shrekli was fully justified in raising the price of that shitty drug. Maybe not to that extent, but he was justified. A drug today costs $800 million and takes 10 years for development and approval, which is why they are patented. Daraprim is a drug is prescribed to ~8000 people in the US and there are better drugs for combatting it. Although the patent is off, no other company is willing to jump through the regulatory hoops to bother producing a drug that is not in common use. Besides, his company focuses on treating rare diseases with low demand on the market, to do that he needs to raise funds and one of the ways to do it is to raise the price of a shitty drug that few use. In fact, the drug is discontinued in Canada because it's bad and there are better alternatives.

I bet deck fires exist in game are "historically accurate" too

Just finished my paper so I will post a bit about infection treatment. First let's talk about sulfa drugs. Sulfa drugs are compounds that produce sulfonamides. They were not antibiotics but antimicrobials since they inhibited further growth of microbes rather than killing them. The first sulfa drug was arsephenamine (Salvarsan), introduced in 1910 and was a pretty shitty drug with terrible adverse effects and were a pain to store and administer. Although it was a shitty drug, it was a good treatment to syphilis, dubbed the 'magic bullet' because it was toxic to certain microbes but not humans. It was the most used antimicrobial until the 1940s. Sulfa drugs became famous due to Prontosil, discovered in 1932. It was widely known because it successfully and quickly treated Franklin Delano Roosevelt's son who had a bad case of strep throat infection. Although it had awful side effects such as vomitting and kidney damage, it became famous and grabbed world wide attention as it was synthetic, showing that synthetic drugs had huge potential and directly killed off phage therapy in the West as the former was much easier to administer and had rapid results. How do sulfa drugs work? Sulfa drugs are either sulfonamides or are pro drugs that break down into sulfonamides. They work by the competitive inhibition of dihydropteroate synthetase (DHPS), responsible for folate synthesis, inhibiting DNA, RNA and protein synthesis. They are broad spectrum against both Gram positive and Gram negative bacteria and are generally used to cure minor infections, especially in the urinary tract. They are terrible for anyone with compromised immune systems because they are bacteriostatic instead of bactericidal. Resistance is very common, with different mechanisms such as decreased membrane permeability, mutated enzymes for the synthesis of folate and increased PABA production to compete for the active sites that the inhibitor takes. Next time, I will post about beta-lactam antibiotics, the most famous of which being penicillin.

And even then, there's nothing stopping Trump from demanding recounts from the swing states Hillary won.

Mr. Stalin's greatest achievement is his eradication of obesity in Ukraine through innovative agricultural reforms.

And he just registered to vote Democrat in 2020!

http://www.independent.co.uk/news/people/donald-trumps-eldest-son-secret-talks-syria-paris-ritz-russia-a7436706.html Trump doing negotiations like how people negotiate to try and find a solution in the Middle East is now bad.

fuck i love the ancap meme balls

The recount doesn't benefit her in any way and it would benefit Hillary the most and she also said that she supports Trump over Hillary earlier. There is little reason for her to only want to recount Trump's swing states and Hillary doesn't want to call it.

Yeah. she received death threats from DNC and Soros.

https://www.thestar.com/news/canada/2016/11/22/trudeau-doing-what-he-promised-he-wouldnt.html Sure loving the new "open" and "transparent" liberal government with more "openness" if you pay $500/plate while "increasing" transparency by repealing the First Nations Financial Transparency Act which required aboriginals to disclose their expenditures to receive federal funding to combat rampant corruption that is plaguing those communities; all while without increasing parliamentary transparency. The difference with the Conservative Party is that they don't at least make promises the opposite of what they were going to do.

The thing with manufacturing is that it creates a lot of wealth. While post-industrial societies with their services can make a lot of money, they won't be creating a lot of wealth. The large disconnect in wealth and money made can create issues when trade is disrupted for whatever reason. High industrialization would in theory produce a more stable economy as it keeps people employed and a lot of wealth can be created. The solution that was proposed just takes the idea even further, with all the advantages and disadvantages.

Liberal arts in university: expensive echo chamber simulator

Maybe it wouldn't have cost nearly as much if the Democrats haven't run a smear campaign against him while riling everyone up to want to murder him

start shit get hit

http://news.nationalpost.com/news/canada/canadian-politics/elizabeth-may-interrupts-michelle-rempel-for-using-unparliamentary-language-the-word-was-f-a-r-t Instead of a rebuttal, Elizabeth May shows why people don't take the Green Party seriously.

is huffpost secretly supporting trump?

And then you read all those fantasy Trump supporters do acts of harassment that are straight out of comic books and then turned out to be false.

"It was merely a jest bro" -All the celebrities that promised to move out of the US after Donald Trump wins

Apparently the union somehow rallied parents to be against her. Honestly, I hate teachers' unions with all my guts. The province where I'm from in canuckistan, Manitoba has the strongest teacher unions in the country. And what do we get out of it? We spend one of the highest amounts per student yet has the lowest test scores in standardized tests. Teachers' unions today are just making sure that the incompetent ones can't get fired under the guise of protection from """arbitrary""" firings at the expense of the future of students and the taxpayer's money. Personally, I had a teacher that was the living example of union protected incompetence. My grade 8 math/science teacher was ridiculously incompetent and is there due to her tenure. We did a non-Newtonian fluid activity with corn starch suspension and she described a suspension fluid as "a substance which has a freezing point really close to its melting point." To make things worse, she gets mad at students for correcting her mistakes, calling them 'rude'. Especially me because I used to correct her a lot as she made a ton of arithmetic errors.

http://www.dailymail.co.uk/news/article-3939586/Woman-dubbed-Public-Enemy-No-1-teachers-unions-eyed-Trump-team-Education-Secretary.html From what I read, she did a fucking amazing job and her policies in DC are merely imitating policies in East Asia, where competent teachers are rewarded and incompetent teachers are punished. Teachers are greatly respected in East Asia because they actually cared about the students as they were rewarded by good performance. Other than incompetent teachers whose jobs are at stake, why the fuck would anyone be against that? That would be presenting a case where the incompetent teachers are more important than the kids' futures.

(((communists))) Almost all communists in the western world today are actually liberals.

Guns should be only controlled for those I don't agree with

Nate Copper every time

I'm writing a paper right now on antibiotics. Might end up writing more on SH about it when I finish. An antibiotic resistant bacteria survives against the antibiotic by having a slightly different mechanism of action in place of the old mechanism that is targeted by the antibiotic. This is highly problematic due to the low generational time of bacteria and plasmid nature of DNA transfer. Low generation time means that a large amount of bacteria will be quickly produced and increases the probably that a bacteria will survive and replicate with a mutation. Now to answer the question, since many antibiotics are biosynthesized, having antibiotic resistance does give them a small selective advantage against the other bacteria that do not have the resistance.