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SuperComrade

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Posts posted by SuperComrade

  1. It is, but there are also advantages in specificity. For example, they would not wipe out gut flora if used for gastrointestinal infections. On the other hand, as you mentioned, accurate diagnosis is crucial.

    There are also concerns about the fact that phages can also transfer genes between bacteria, which can have unintended effects.

    Incidentally, one of Gerhard Domagk's first patients for Prontosil was dyed permanently pink by the drug (it was developed from a dye), though she survived the infection. She was his daughter.

  2. Sulfa drugs (among the most famous of which was Prontosil) were the first truly effective antibacterial agents, and were widely used in the West in the years preceding World War II, and remained in widespread use in Germany until the end of the war.

    Penicillin, discovered by Fleming and made practical by Chain and Florey, was the first antibiotic to be discovered. It replaced sulfa drugs in the second half of World War II among the Allied forces after tremendous problems with mass production were overcome.

    Phage therapy (the use of bacteriophage viruses to destroy harmful bacteria) remained popular in the Soviet Union long after the West switched over to sulfa drugs and, later, antibiotics. It is still in use today in the former USSR, though concerns with using an evolving, self-replicating entity in medical treatments has thus far prevented their use in the West.

    Discuss them here.


     

  3. In the long run, I honestly think the Lunokhod program was more influential when it comes to space exploration. Apollo was definitely one of the greatest achievements of mankind. But when it comes to long term impact, the rover technology pioneered by the Soviets has proved more important so far.

     

    STS was an attempt to make space travel more affordable and thus accessible by having a reuseable spacecraft. Unfortunately, at this point, STS didn't prove as economical as hoped, which ultimately led to pressures on NASA to cut on costs and skip steps, which are a lot of the reasons why Challenger and Columbia happened.

  4. Well, for one thing, they were titanium hulled, which is very difficult to build with and also really expensive.

     

    Liquid metal reactors also means they had to be kept above a certain temperature constantly, or the liquid metal would solidify

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