ShamefurDispray
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Posts posted by ShamefurDispray
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Alas, the AFT skill only provides a 4% boost to the range of the Novik's main guns instead of the skill's advertised 20% boost. WG support first lied to me, saying that my AFT skill didn't work because I didn't have a third level captain skill selected. Now ignoring the fact that my screen shots clearly showed all four skill levels, how could the game even allow a Level 4 skill without a Level 3 skill? That in itself should have been a major bug. I then responded with new screenshots with each of my selected skills circled in red. Finally, they got around to contacting the developers who supposedly claimed that the range hard cap was for "historical" accuracy.
I bet deck fires exist in game are "historically accurate" too
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Just finished my paper so I will post a bit about infection treatment. First let's talk about sulfa drugs.
Sulfa drugs are compounds that produce sulfonamides. They were not antibiotics but antimicrobials since they inhibited further growth of microbes rather than killing them. The first sulfa drug was arsephenamine (Salvarsan), introduced in 1910 and was a pretty shitty drug with terrible adverse effects and were a pain to store and administer. Although it was a shitty drug, it was a good treatment to syphilis, dubbed the 'magic bullet' because it was toxic to certain microbes but not humans. It was the most used antimicrobial until the 1940s.
Sulfa drugs became famous due to Prontosil, discovered in 1932. It was widely known because it successfully and quickly treated Franklin Delano Roosevelt's son who had a bad case of strep throat infection. Although it had awful side effects such as vomitting and kidney damage, it became famous and grabbed world wide attention as it was synthetic, showing that synthetic drugs had huge potential and directly killed off phage therapy in the West as the former was much easier to administer and had rapid results.
How do sulfa drugs work? Sulfa drugs are either sulfonamides or are pro drugs that break down into sulfonamides. They work by the competitive inhibition of dihydropteroate synthetase (DHPS), responsible for folate synthesis, inhibiting DNA, RNA and protein synthesis. They are broad spectrum against both Gram positive and Gram negative bacteria and are generally used to cure minor infections, especially in the urinary tract. They are terrible for anyone with compromised immune systems because they are bacteriostatic instead of bactericidal.
Resistance is very common, with different mechanisms such as decreased membrane permeability, mutated enzymes for the synthesis of folate and increased PABA production to compete for the active sites that the inhibitor takes.
Next time, I will post about beta-lactam antibiotics, the most famous of which being penicillin.
- SuperComrade and Collimatrix
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It seems extremely unlikely that a recount would change the outcome. The 2000 election hung by Florida by a margin of 500-something votes. By changing which method was used to count marginal ballots, either Gore or Bush could have gotten Florida, but only by a margin of a few hundred votes. For a recount to change the results of this election, multiple states would have to change their results by thousands of votes. That's compound unlikely.
And even then, there's nothing stopping Trump from demanding recounts from the swing states Hillary won.
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So I guess there is a trending pound sign on Twitter called #TrudeauEulogies
Mr. Stalin's greatest achievement is his eradication of obesity in Ukraine through innovative agricultural reforms.
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Castro is kill for real:
And he just registered to vote Democrat in 2020!
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Trump doing negotiations like how people negotiate to try and find a solution in the Middle East is now bad.
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fuck i love the ancap meme balls
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You mean that they'd off her if she didn't do it?
The recount doesn't benefit her in any way and it would benefit Hillary the most and she also said that she supports Trump over Hillary earlier. There is little reason for her to only want to recount Trump's swing states and Hillary doesn't want to call it.
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Nice, you think this BS with Stein challenging the election results in three key states has any legs?
Yeah. she received death threats from DNC and Soros.
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https://www.thestar.com/news/canada/2016/11/22/trudeau-doing-what-he-promised-he-wouldnt.html
Sure loving the new "open" and "transparent" liberal government with more "openness" if you pay $500/plate while "increasing" transparency by repealing the First Nations Financial Transparency Act which required aboriginals to disclose their expenditures to receive federal funding to combat rampant corruption that is plaguing those communities; all while without increasing parliamentary transparency.
The difference with the Conservative Party is that they don't at least make promises the opposite of what they were going to do.
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A bit of trivia dug up from the before times:
I think the diagnosis of the problem is correct in the greater scheme of things, but the proposed solutions are hilarious. Education, healthcare and green energy. Really? That's what's going to provide a living wage to the 25% of the population left behind after manufacturing?
The true takeaway here, I think, is that nobody has the right answer yet. Heck there may not even be one, at least if you constrain the possible answers to those that include 95% employment of working age citizens.
We're all in the dark here.
The thing with manufacturing is that it creates a lot of wealth. While post-industrial societies with their services can make a lot of money, they won't be creating a lot of wealth. The large disconnect in wealth and money made can create issues when trade is disrupted for whatever reason. High industrialization would in theory produce a more stable economy as it keeps people employed and a lot of wealth can be created.
The solution that was proposed just takes the idea even further, with all the advantages and disadvantages.
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Protecting Trump is apparently costing NYC $1million a day.
Maybe it wouldn't have cost nearly as much if the Democrats haven't run a smear campaign against him while riling everyone up to want to murder him
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Instead of a rebuttal, Elizabeth May shows why people don't take the Green Party seriously.
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is huffpost secretly supporting trump?
- AdmiralTheisman, T___A and Donward
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Don't you know that this whole election has been basically the progressive left projecting onto everyone else?
I mean, look at Arthur Chu. He railed on at people for years about what a bunch of sexist misogynists they were, how they didn't appreciate women enough, etc.
Recently his wife dumped him because he made her do all the housework and clean up all his shit and he took her for granted and was useless.
I'm not absolving the right here, and I was worried that if Hillary won (especially if it was close, or if she didn't win the popular vote but did win the electoral vote) some Trump supporters would go ape. Just that this whole time the progressive left has projected their worst aspects all over everyone.
And then you read all those fantasy Trump supporters do acts of harassment that are straight out of comic books and then turned out to be false.
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"It was merely a jest bro" -All the celebrities that promised to move out of the US after Donald Trump wins
including Lena Dunham who promised to move to Canada thank god
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I think you answered your own question.
Apparently the union somehow rallied parents to be against her.
Honestly, I hate teachers' unions with all my guts.
The province where I'm from in canuckistan, Manitoba has the strongest teacher unions in the country. And what do we get out of it?
We spend one of the highest amounts per student yet has the lowest test scores in standardized tests. Teachers' unions today are just making sure that the incompetent ones can't get fired under the guise of protection from """arbitrary""" firings at the expense of the future of students and the taxpayer's money.
Personally, I had a teacher that was the living example of union protected incompetence. My grade 8 math/science teacher was ridiculously incompetent and is there due to her tenure. We did a non-Newtonian fluid activity with corn starch suspension and she described a suspension fluid as "a substance which has a freezing point really close to its melting point."
To make things worse, she gets mad at students for correcting her mistakes, calling them 'rude'. Especially me because I used to correct her a lot as she made a ton of arithmetic errors.
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From what I read, she did a fucking amazing job and her policies in DC are merely imitating policies in East Asia, where competent teachers are rewarded and incompetent teachers are punished. Teachers are greatly respected in East Asia because they actually cared about the students as they were rewarded by good performance.
Other than incompetent teachers whose jobs are at stake, why the fuck would anyone be against that? That would be presenting a case where the incompetent teachers are more important than the kids' futures.
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Shits rough when the actual communist thinks you're too far to the left
(((communists)))
Almost all communists in the western world today are actually liberals.
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Recently, an NYC journalist who has posted numerous anti-gun hit pieces in the past made the comment that "Huh, we might need to buy AR-15s right now." And is encouraging people to "arm up".
My favorite bit from the thread.
Guns should be only controlled for those I don't agree with
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I'm writing a paper right now on antibiotics. Might end up writing more on SH about it when I finish.
As for antibiotic resistance, yeah that's no bueno. Local populations of bacteria that are resistant would not be good. Although, I'm not sure what kind of evolutionary advantage it would give a certain population over another in an open environment (aka, not a feed lot), so I don't see the resistant plasmids completely overtaking very quickly.
An antibiotic resistant bacteria survives against the antibiotic by having a slightly different mechanism of action in place of the old mechanism that is targeted by the antibiotic. This is highly problematic due to the low generational time of bacteria and plasmid nature of DNA transfer. Low generation time means that a large amount of bacteria will be quickly produced and increases the probably that a bacteria will survive and replicate with a mutation. Now to answer the question, since many antibiotics are biosynthesized, having antibiotic resistance does give them a small selective advantage against the other bacteria that do not have the resistance.
General news thread
in Open Discussion
Posted
Shrekli was fully justified in raising the price of that shitty drug. Maybe not to that extent, but he was justified.
A drug today costs $800 million and takes 10 years for development and approval, which is why they are patented. Daraprim is a drug is prescribed to ~8000 people in the US and there are better drugs for combatting it. Although the patent is off, no other company is willing to jump through the regulatory hoops to bother producing a drug that is not in common use.
Besides, his company focuses on treating rare diseases with low demand on the market, to do that he needs to raise funds and one of the ways to do it is to raise the price of a shitty drug that few use. In fact, the drug is discontinued in Canada because it's bad and there are better alternatives.